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200 years after Ellen Ripley's death,cite-ref-6[a] military scientists aboard the space vessel USM Auriga create a clone of her, designated Ripley 8, using DNA from blood samples taken from Fiorina "Fury" 161. The Xenomorph queen's DNA has been combined with Ripley's, resulting in the clone growing up with an embryo inside it. The scientists extract the embryo, raise it, and collect its eggs while keeping Ripley 8 alive for further study. As a result of the Xenomorph queen's DNA, the clone possesses enhanced strength and reflexes, acidic blood, and a psychic link with the Xenomorphs, making her more empathetic toward them than the humans she encounters. Additionally, the Xenomorph's genetic memory allows the clone to retain some of Ripley's memories.

A group of mercenaries—Elgyn, Johner, Christie, Vriess, Hillard, and Call—arrives at the Auriga on their ship, the Betty, delivering several abducted humans in stasis. The military scientists use the humans as hosts for the aliens, raising several adult Xenomorphs for study.

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